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Issue 32, 2015
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Selective cell elimination in vitro and in vivo from tissues and tumors using antibodies conjugated with a near infrared phthalocyanine

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Abstract

Cell cultures and tissues often contain cellular subpopulations that potentially interfere with or contaminate other cells of interest. However, it is difficult to eliminate unwanted cells without damaging the very cell population one is seeking to protect, especially established tissue. Here, we report a method of eliminating a specific subpopulation of cells from a mixed 2D or 3D cell culture in vitro and a mixed-population in vivo tumor model by using antibody-photosensitizer conjugates (APC) with a near infrared (NIR) phthalocyanine-derivative (IRdye700DX, IR700) combined with NIR light exposure with minimal damage to non-targeted cells. Thus, APC combined with NIR light exposure holds promise as a method of removing specific cells from mixed cell cultures and tumors.

Graphical abstract: Selective cell elimination in vitro and in vivo from tissues and tumors using antibodies conjugated with a near infrared phthalocyanine

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Supplementary files

Article information


Submitted
04 Nov 2014
Accepted
02 Mar 2015
First published
03 Mar 2015

RSC Adv., 2015,5, 25105-25114
Article type
Paper
Author version available

Selective cell elimination in vitro and in vivo from tissues and tumors using antibodies conjugated with a near infrared phthalocyanine

K. Sato, T. Nakajima, P. L. Choyke and H. Kobayashi, RSC Adv., 2015, 5, 25105
DOI: 10.1039/C4RA13835J

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