Issue 9, 2015
From the journal:

RSC Advances

Metal-free radical perfluoroalkylation of (hetero)arenes†

Sabilla Zhong,a   Andreas Hafner,a   Christoph Hussal,a   Martin Niegerb  and  Stefan Bräse*ac  

* Corresponding authors

a Karlsruhe Institute of Technology (KIT), Institute of Organic Chemistry, Fritz-Haber-Weg 6, D-76131 Karlsruhe, Germany
E-mail: braese@kit.edu
Tel: +49-721-608-48581

b Laboratory of Inorganic Chemistry, Department of Chemistry, University of Helsinki, P. O. Box 55, Finland

c Institute of Toxicology and Genetics, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany

Abstract

We report a metal-free radical perfluoroalkylation method which uses inexpensive and commercially available perfluorocarboxylic anhydrides as an easy to use source of perfluoroalkyl radicals. This approach allows the perfluoroalkylation of different arenes, such as benzene derivatives, furans, thiophenes, and pyrroles, including highly functionalized compounds.

Graphical abstract: Metal-free radical perfluoroalkylation of (hetero)arenes

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Article information

DOI
https://doi.org/10.1039/C4RA13430C
Article type
Communication
Submitted
29 Oct 2014
Accepted
15 Dec 2014
First published
15 Dec 2014

RSC Adv., 2015,5, 6255-6258

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Metal-free radical perfluoroalkylation of (hetero)arenes

S. Zhong, A. Hafner, C. Hussal, M. Nieger and S. Bräse, RSC Adv., 2015, 5, 6255 DOI: 10.1039/C4RA13430C

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