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Issue 2, 2015

A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

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Abstract

An efficient and gram-scale continuous-flow protocol for the synthesis of the privileged structure 3,4-dihydro-5H-benzo[e][1,4]diazepin-5-one is reported. If compared to the traditional metal mediated non-catalytic reduction procedure, this approach is high yielding and does not require purification steps and therefore could be conveniently used for the generation of compound libraries for drug discovery.

Graphical abstract: A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

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Article information


Submitted
29 Oct 2014
Accepted
27 Nov 2014
First published
27 Nov 2014

RSC Adv., 2015,5, 1268-1273
Article type
Paper
Author version available

A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery

M. Viviano, C. Milite, D. Rescigno, S. Castellano and G. Sbardella, RSC Adv., 2015, 5, 1268 DOI: 10.1039/C4RA13392G

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