The synthesis of benzo[g]chromene derivatives through a multi-component reaction catalyzed by lipase is reported for the first time. This novel efficient method has the advantages of environmental friendliness, high yield and simple work-up. Moreover, this protocol extends the phenomenon of enzyme promiscuity.
![Graphical abstract: A green and one-pot synthesis of benzo[g]chromene derivatives through a multi-component reaction catalyzed by lipase](/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C4RA13272F&imageInfo.ImageIdentifier.Year=2015)
F. Yang, H. Wang, L. Jiang, H. Yue, H. Zhang, Z. Wang and L. Wang, RSC Adv., 2015, 5, 5213 DOI: 10.1039/C4RA13272F
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