Issue 12, 2015
From the journal:

RSC Advances

Acid-responsive nanospheres from an asparagine-derived amphiphile†

Adelphe M. Mfuh,a   Mathew P. D. Mahindaratne,b   Audrey E. Yñigez-Gutierrez,a   Juan R. Ramos Dominguez,a   Jefferson T. Bedell II,a   Carlos D. Garciaa  and  George R. Negrete*a  

* Corresponding authors

a Department of Chemistry, University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249-1644, USA
E-mail: george.negrete@utsa.edu

b Texas A&M University-San Antonio, One University Way, San Antonio, TX 78224, USA
Fax: +1 210 458-7428
Tel: +1 210 458-5448

Abstract

We describe the synthesis and self-assembly of an asparagine-derived amphiphile. The self-assembled systems formulated with the inclusion of cholesterol (0–50 mol%) show encapsulation for a hydrophobic model drug and rapidly disintegrate in response to mild acidic conditions.

Graphical abstract: Acid-responsive nanospheres from an asparagine-derived amphiphile

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Article information

DOI
https://doi.org/10.1039/C4RA11884G
Article type
Communication
Submitted
06 Oct 2014
Accepted
23 Dec 2014
First published
23 Dec 2014

RSC Adv., 2015,5, 8585-8590

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Acid-responsive nanospheres from an asparagine-derived amphiphile

A. M. Mfuh, M. P. D. Mahindaratne, A. E. Yñigez-Gutierrez, J. R. Ramos Dominguez, J. T. Bedell II, C. D. Garcia and G. R. Negrete, RSC Adv., 2015, 5, 8585 DOI: 10.1039/C4RA11884G

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