Valeriadimers A–C, three sesquiterpenoid dimers from valeriana officinalis var. latifolia

Abstract

Valeriadimer A (1), formed by a C–C (4-1′) bond between a bicyclogermacrane nor-sesquiterpene moiety and a maaliane nor-sesquiterpene moiety, together with two further sesquiterpenoid dimers, valeriadimers B and C (2, 3) were isolated from the root of Valeriana officinalis var. latifolia. Their structures were elucidated by extensive analysis of spectroscopic data and confirmed by Cu-Kα X-ray diffraction experiment.