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Issue 9, 2015
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Chemoselective hydration of nitriles to amides using hydrated ionic liquid (IL) tetrabutylammonium hydroxide (TBAH) as a green catalyst

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Abstract

A transition metal-free process, catalyzed by tetrabutylammonium hydroxide (TBAH), has been developed for the convenient and selective hydration of nitriles to the corresponding amides. The present process converts aromatic, aliphatic, and heteroaromatic nitriles with a wide variety of functional groups into amides. The regioselective hydration of one nitrile moiety in the presence of another nitrile group gives the present protocol high impact.

Graphical abstract: Chemoselective hydration of nitriles to amides using hydrated ionic liquid (IL) tetrabutylammonium hydroxide (TBAH) as a green catalyst

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Article information


Submitted
05 Sep 2014
Accepted
16 Dec 2014
First published
17 Dec 2014

RSC Adv., 2015,5, 6365-6371
Article type
Paper
Author version available

Chemoselective hydration of nitriles to amides using hydrated ionic liquid (IL) tetrabutylammonium hydroxide (TBAH) as a green catalyst

H. Veisi, B. Maleki, M. Hamelian and S. S. Ashrafi, RSC Adv., 2015, 5, 6365
DOI: 10.1039/C4RA09864A

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