A mild and efficient catalytic system based on PdCl2 and Na2SO4 has been developed for the Sonogashira reaction of aryl iodides at room temperature. The system provides a simple route to obtain polyfunctional alkynes under ligand and copper free conditions. The procedure is equally efficient for aliphatic alkynes and aryl bromides.
A. Gogoi, A. Dewan and U. Bora, RSC Adv., 2015, 5, 16 DOI: 10.1039/C4RA09630D
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