Issue 8, 2015
From the journal:

Organic Chemistry Frontiers

Palladium-catalyzed direct ortho C–O bond construction of azoxybenzenes with carboxylic acids and alcohols†

Duo Zhang,a   Xiuling Cui,*ab   Fangfang Yang,a   Qianqian Zhang,a   Yu Zhua  and  Yangjie Wu*a  

* Corresponding authors

a Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, P. R. China
E-mail: cuixl@zzu.edu.cn

b Xiamen Key Laboratory of Ocean and Gene Drugs, School of Biomedical Sciences, Institute of Molecular Medicine of Huaqiao University and Engineering Research Centre of Molecular Medicine of the Chinese Education Ministry, Xiamen, Fujian 361021, P. R. China

Abstract

A Pd(II) catalyzed C–O bond formation of azoxybenzenes has been developed. An N-atom served as a directing group, as confirmed by the single crystal X-ray diffraction analysis of the palladium complex. The products were obtained in moderate to excellent yields for 29 examples. This protocol features high regioselectivity, wide functional group tolerance and atom economy.

Graphical abstract: Palladium-catalyzed direct ortho C–O bond construction of azoxybenzenes with carboxylic acids and alcohols

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Article information

DOI
https://doi.org/10.1039/C5QO00120J
Article type
Research Article
Submitted
12 Apr 2015
Accepted
02 Jun 2015
First published
03 Jun 2015

Org. Chem. Front., 2015,2, 951-955

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Palladium-catalyzed direct ortho C–O bond construction of azoxybenzenes with carboxylic acids and alcohols

D. Zhang, X. Cui, F. Yang, Q. Zhang, Y. Zhu and Y. Wu, Org. Chem. Front., 2015, 2, 951 DOI: 10.1039/C5QO00120J

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