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Issue 6, 2015
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Atroposelective synthesis of axially chiral P,S-ligands based on arynes

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Abstract

The first atropo-selective aryl–aryl coupling based on arynes in the presence of a tert-butylsulfinyl group as the chiral auxiliary on the aryllithium nucleophile is described. The approach allows for the efficient access to a novel family of atropo-enantiopure biphenyl-based phosphine–thioether ligands. The new P,S heterodonor ligands were assessed in model palladium-catalyzed allylic substitution reactions.

Graphical abstract: Atroposelective synthesis of axially chiral P,S-ligands based on arynes

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The article was received on 27 Feb 2015, accepted on 05 Apr 2015 and first published on 09 Apr 2015


Article type: Research Article
DOI: 10.1039/C5QO00067J
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Org. Chem. Front., 2015,2, 634-644

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    Atroposelective synthesis of axially chiral P,S-ligands based on arynes

    A. Berthelot-Bréhier, A. Panossian, F. Colobert and F. R. Leroux, Org. Chem. Front., 2015, 2, 634
    DOI: 10.1039/C5QO00067J

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