Selective formation of C–N and CN bonds via C(sp3)–H activation of isochroman in the presence of DTBP

Abstract

An approach for the synthesis of isochroman derivatives via direct C(sp³)–H bond and N–H bond coupling is described. The C–N (amine or amide) and CN (imidate) products can be selectively achieved by controlling the amount of oxidants. Moreover, this metal- and base-free protocol is simple, easy-to-handle, and atom-economical which may have potential application in drug synthesis.