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Issue 45, 2015
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Synthetic glycopolypeptides: synthesis and self-assembly of poly(γ-benzyl-l-glutamate)-glycosylated dendron hybrids

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Abstract

Nano-assemblies prepared from glycosylated macromolecules are promising systems for modulating or mimicking the interactions between natural carbohydrates and their receptors. In the current work, polyester dendrons bearing focal point alkynes and peripheral C-linked α-galactose moieties were synthesized and coupled to helical poly(γ-benzyl-L-glutamate) (PBLG) to afford synthetic linear-dendritic glycopolypeptides. Both the dendrimer generation and the length of the PBLG were varied to provide a small library of amphiphiles with hydrophilic mass fractions ranging from 0.07 to 0.54. The self-assembly of the copolymers in water using a solvent exchange method was optimized and studied in detail. While the linear-dendritic copolymers composed of lower generation dendrons tended to aggregate, a copolymer composed of a 4th generation galactose-functionalized dendron and PBLG with a degree of polymerization of 28 formed micellar nano-assemblies whose size could be tuned by varying the self-assembly process. Overall, this study provides new insights into the effects of polymer architecture on self-assembly properties, while at the same time introducing a new platform for the preparation of bioactive nanoparticles.

Graphical abstract: Synthetic glycopolypeptides: synthesis and self-assembly of poly(γ-benzyl-l-glutamate)-glycosylated dendron hybrids

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Supplementary files

Article information


Submitted
08 Jul 2015
Accepted
20 Sep 2015
First published
22 Sep 2015

Polym. Chem., 2015,6, 7902-7912
Article type
Paper
Author version available

Synthetic glycopolypeptides: synthesis and self-assembly of poly(γ-benzyl-L-glutamate)-glycosylated dendron hybrids

A. Peyret, J. F. Trant, C. V. Bonduelle, K. Ferji, N. Jain, S. Lecommandoux and E. R. Gillies, Polym. Chem., 2015, 6, 7902
DOI: 10.1039/C5PY01060H

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