Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 17, 2015
Previous Article Next Article

Dual side chain control in the synthesis of novel sequence-defined oligomers through the Ugi four-component reaction

Author affiliations

Abstract

The synthesis of sequence-defined oligomers by the iterative application of the modular Ugi four-component reaction (U-4CR) and the efficient thiol–ene addition reaction is described. By varying the amine component in the U-4CR, a sequence-defined and monodisperse tetramer (M = 1568.5 g mol−1) was obtained. More interestingly, if both the amine and the isocyanide components were varied simultaneously in the U-4CR, a double sequence-controlled, monodisperse pentamer (M = 2411.8 g mol−1) bearing ten different and selectable side chains was obtained. All oligomers were thoroughly characterized by NMR and IR spectroscopy, mass spectrometry and GPC.

Graphical abstract: Dual side chain control in the synthesis of novel sequence-defined oligomers through the Ugi four-component reaction

Back to tab navigation

Supplementary files

Article information


Submitted
23 Mar 2015
Accepted
23 Mar 2015
First published
24 Mar 2015

Polym. Chem., 2015,6, 3201-3204
Article type
Communication

Dual side chain control in the synthesis of novel sequence-defined oligomers through the Ugi four-component reaction

S. C. Solleder, K. S. Wetzel and M. A. R. Meier, Polym. Chem., 2015, 6, 3201
DOI: 10.1039/C5PY00424A

Social activity

Search articles by author

Spotlight

Advertisements