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Issue 16, 2015
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One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging

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Abstract

Highly cross-linked and monodispersed polyphosphazene nanoparticles (NPs) exhibiting strong fluorescence were prepared by a remarkably simple one-pot polycondensation of hexachlorocyclotriphosphazene (HCCP) and 4,5-dibromofluorescein (DBF). The morphology and size of the resulting poly(cyclotriphosphazene-co-dibromofluorescein) (PCTPDBF) NPs can be facilely tuned by varying the solvent and reactant concentration. The fluorescent DBF units were isolated and “fastened” in the cross-linked structures, which can well suppress the concentration-quenching effect of small fluorescent probes. Hence, the PCTPDBF NPs can emit bright yellow fluorescence at any concentration. The PCTPDBF NPs could enter HeLa and H9C2 cells and were located in the cytoplasm. Combined with their excellent biocompatibility and improved resistance to photobleaching and protein interference, they can be used as ideal fluorescent agents for cell imaging.

Graphical abstract: One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging

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Supplementary files

Article information


Submitted
06 Feb 2015
Accepted
10 Mar 2015
First published
12 Mar 2015

Polym. Chem., 2015,6, 3155-3163
Article type
Paper
Author version available

One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging

L. Meng, C. Xu, T. Liu, H. Li, Q. Lu and J. Long, Polym. Chem., 2015, 6, 3155
DOI: 10.1039/C5PY00196J

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