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Three aryl hydrazide foldamer polymers, which bear different numbers of chiral pentaethylene glycol chains, have been synthesized. Circular dichroism and UV-vis studies reveal that two of them can be driven by hydrophobicity to form helical hollow conformation in water that exhibit strong twist sense bias.

Graphical abstract: Hydrophobically driven twist sense bias of hollow helical foldamers of aromatic hydrazide polymers in water

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