A diphenyl ether derived bidentate secondary phosphine oxide as a preligand for nickel-catalyzed C–S cross-coupling reactions†
Abstract
A new bidentate secondary phosphine oxide (SPO) was synthesized from diphenyl ether via ortho-lithiation, phosphorylation with PhP(Cl)NEt2, and hydrolysis in an acidic medium. Nickel(0) species ligated with this new SPO was established as a more effective catalyst than Ni(0)–Ph2P(O)H for the cross-coupling of aryl iodides with aryl thiols.