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Issue 47, 2015
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TBHP/TFA mediated oxidative cross-dehydrogenative coupling of N-heterocycles with aldehydes

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Abstract

An effective and metal-free oxidative cross-dehydrogenative coupling (CDC) of N-heterocycles with diverse aldehydes has been established in the presence of TBHP/TFA. The scope with respect to aldehyde and N-heterocycle components is broad, allowing facile synthesis of a broad range of structurally diverse C1-acyl substituted heterocycles in good efficiency.

Graphical abstract: TBHP/TFA mediated oxidative cross-dehydrogenative coupling of N-heterocycles with aldehydes

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Article information


Submitted
22 Aug 2015
Accepted
30 Sep 2015
First published
01 Oct 2015

Org. Biomol. Chem., 2015,13, 11561-11566
Article type
Paper

TBHP/TFA mediated oxidative cross-dehydrogenative coupling of N-heterocycles with aldehydes

J. Chen, M. Wan, J. Hua, Y. Sun, Z. Lv, W. Li and L. Liu, Org. Biomol. Chem., 2015, 13, 11561
DOI: 10.1039/C5OB01763G

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