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Issue 42, 2015
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The development of a short route to the API ropinirole hydrochloride

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Abstract

A four-step, three-stage synthesis of the API ropinirole hydrochloride has been developed from a commercially available naphthalene derivative. The new route has half the step-count and twice the overall yield of the current manufacturing process. Key features of the synthesis are a regioselective Birch reduction and an ozonolysis with concomitant ring closure to induce the required ring contraction.

Graphical abstract: The development of a short route to the API ropinirole hydrochloride

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Article information


Submitted
19 Aug 2015
Accepted
28 Aug 2015
First published
28 Aug 2015

Org. Biomol. Chem., 2015,13, 10532-10539
Article type
Paper
Author version available

The development of a short route to the API ropinirole hydrochloride

Z. Yousuf, A. K. Richards, A. N. Dwyer, B. Linclau and D. C. Harrowven, Org. Biomol. Chem., 2015, 13, 10532
DOI: 10.1039/C5OB01739D

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