Min Jiang, Haoyue Xiang, Fangxia Zhu, Xing Xu, Lianfu Deng and Chunhao Yang
Org. Biomol. Chem., 2015,13, 10122-10126
DOI:
10.1039/C5OB01642H,
Communication
An efficient and practical one-pot domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives from readily available 2-(2-bromophenyl)acetonitriles was developed. The overall protocol involves a Buchwald–Hartwig type coupling and a base-promoted intramolecular nucleophilic reaction. The reaction scope, advantages and limitations are discussed.
![Graphical abstract: Efficient Pd-catalyzed domino synthesis of 1-phenyl-1H-indol-2-amine and 5-amino-indolo[1,2-a]quinazoline derivatives](/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C5OB01642H "Graphical abstract")
