Issue 43, 2015

Synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles under catalyst-free conditions

Abstract

A convenient procedure for the synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles has been developed. By using KOtBu as the promotor with 2-aminopyridines or amidines as the reaction partner, the desired heterocycles were produced in moderate to good yields under catalyst-free conditions.

Graphical abstract: Synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles under catalyst-free conditions

Supplementary files

Article information

Article type
Paper
Submitted
30 Jul 2015
Accepted
27 Aug 2015
First published
27 Aug 2015

Org. Biomol. Chem., 2015,13, 10656-10662

Author version available

Synthesis of quinazolinimines and quinazolinamines from 2-fluorobenzonitriles under catalyst-free conditions

J. Feng and X. Wu, Org. Biomol. Chem., 2015, 13, 10656 DOI: 10.1039/C5OB01587A

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