Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.

Issue 2, 2016
Previous Article Next Article

Synthesis and characterisation of a mesocyclic tripodal triamine ligand

Author affiliations


Meso- and macrocyclic polydentate amine ligands have been widely explored in oxidation catalysis and for the stabilization of unstable metal-superoxide, -peroxide, and -oxo intermediates. Herein we report on the design and synthesis of a novel mesocyclic, tripodal, triamine ligand that we believe will be an excellent addition to this field. We explored a number of synthetic procedures towards the mesocyclic asymmetric tetraalkylated ligand 1. We expect that 1 will bind metals in a facially capping manner, yielding complexes that display pseudo-tetrahedral geometry, potentially providing access to unprecedented late transition metal-oxo complexes (metal = Co, Ni, Cu). We describe the preparation of a library of mesocyclic polyamine synthons (8, 16, 17, 18, 19) that are precursors in the synthesis of 1. These synthons will be used to tailor the electronic properties of metal complexes of 1 and derivatives thereof. The X-ray crystal structures of 19 and mono- and di-protonated forms of 1b show that the triamine crystalises in a boat–chair conformation which is undesirable for metal coordination. However, solution 1H NMR studies show that in solution both 19 and the tetraalkylated derivative 1b are remarkably flexible. 1b reacted with [CuI(NCCH3)4](OTf) yielding a 1 : 1 copper(I) complex [CuI(NCCH3)(1b)]+.

Graphical abstract: Synthesis and characterisation of a mesocyclic tripodal triamine ligand

Back to tab navigation

Supplementary files

Article information

27 Jul 2015
14 Oct 2015
First published
14 Oct 2015

Org. Biomol. Chem., 2016,14, 483-494
Article type
Author version available

Synthesis and characterisation of a mesocyclic tripodal triamine ligand

A. D. Ure, I. A. Lázaro, M. Cotter and A. R. McDonald, Org. Biomol. Chem., 2016, 14, 483
DOI: 10.1039/C5OB01556A

Social activity

Search articles by author