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Issue 39, 2015
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Emerging trends in enzyme inhibition by multivalent nanoconstructs

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Abstract

Multivalent nanoconstructs, extensively used for enhancing the recognition of biomolecular targets, have been recently exploited for enzyme inhibition showing interesting properties such as improvement of inhibitory potency and selectivity. We review herein the recent results highlighting the potential of multivalent nanoconstructs for the inhibition of different enzymes, and the emerging trends in the generation and identification of multivalent clusters as enzyme inhibitors.

Graphical abstract: Emerging trends in enzyme inhibition by multivalent nanoconstructs

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Article information


Submitted
10 Jul 2015
Accepted
24 Aug 2015
First published
24 Aug 2015

Org. Biomol. Chem., 2015,13, 9894-9906
Article type
Review Article

Emerging trends in enzyme inhibition by multivalent nanoconstructs

N. Kanfar, E. Bartolami, R. Zelli, A. Marra, J. Winum, S. Ulrich and P. Dumy, Org. Biomol. Chem., 2015, 13, 9894
DOI: 10.1039/C5OB01405K

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