Issue 31, 2015
From the journal:

Organic & Biomolecular Chemistry

Iridium/copper-cocatalyzed asymmetric ring opening reaction of azabenzonorbornadienes with amines†

Chaoyuan Zeng,a   Fan Yang,a   Jingchao Chen,a   Jun Wang*b  and  Baomin Fan*a  

* Corresponding authors

a YMU-HKBU Joint Laboratory of Traditional Natural Medicine, Yunnan Minzu University, Kunming 650500, China
E-mail: adams.bmf@hotmail.com
Fax: (+86)-871-65913103

b Department of Chemistry, South University of Science and Technology of China, Shenzhen, Guangdong, China
E-mail: wang.j@sustc.edu.cn
Fax: (+86)-755-88018304

Abstract

A combination of iridium/copper associated with (R)-Difluorphos catalyst for the asymmetric ring opening reaction of azabenzonorbornadienes with amines was developed, which afforded chiral trans-vicinal diamines in 80–97% yields with 93–95% enantioselectivities.

Graphical abstract: Iridium/copper-cocatalyzed asymmetric ring opening reaction of azabenzonorbornadienes with amines

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Article information

DOI
https://doi.org/10.1039/C5OB01243K
Article type
Communication
Submitted
18 Jun 2015
Accepted
08 Jul 2015
First published
09 Jul 2015

Org. Biomol. Chem., 2015,13, 8425-8428

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Iridium/copper-cocatalyzed asymmetric ring opening reaction of azabenzonorbornadienes with amines

C. Zeng, F. Yang, J. Chen, J. Wang and B. Fan, Org. Biomol. Chem., 2015, 13, 8425 DOI: 10.1039/C5OB01243K

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