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Issue 29, 2015
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A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

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Abstract

Herein we report the use of bromomaleimides for the construction of stable albumin conjugates via conjugation to its native, single accessible, cysteine followed by hydrolysis. Advantages over the classical maleimide approach are highlighted in terms of quantitative hydrolysis and absence of undesirable retro-Michael deconjugation.

Graphical abstract: A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

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Article information


Submitted
12 Jun 2015
Accepted
17 Jun 2015
First published
17 Jun 2015

This article is Open Access

Org. Biomol. Chem., 2015,13, 7946-7949
Article type
Paper

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine

M. E. B. Smith, M. B. Caspersen, E. Robinson, M. Morais, A. Maruani, J. P. M. Nunes, K. Nicholls, M. J. Saxton, S. Caddick, J. R. Baker and V. Chudasama, Org. Biomol. Chem., 2015, 13, 7946
DOI: 10.1039/C5OB01205H

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