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Issue 31, 2015
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Copper-catalyzed trifluoromethylation of alkenes: synthesis of trifluoromethylated benzoxazines

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Abstract

A simple base and ligand free copper catalyzed method for the construction of trifluoromethylated benzoxazines has been developed by using Umemoto's reagent. It involves the oxidative difunctionalization of alkenes through tandem C–O and C–CF3 bond formations. Furthermore, synthesized benzoxazines were selectively converted into trifluoromethylated allylic and (E)-vinylic benzamides by the treatment of KOtBu and CH3Li, respectively.

Graphical abstract: Copper-catalyzed trifluoromethylation of alkenes: synthesis of trifluoromethylated benzoxazines

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Publication details

The article was received on 11 Jun 2015, accepted on 02 Jul 2015 and first published on 03 Jul 2015


Article type: Communication
DOI: 10.1039/C5OB01196E
Citation: Org. Biomol. Chem., 2015,13, 8411-8415
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    Copper-catalyzed trifluoromethylation of alkenes: synthesis of trifluoromethylated benzoxazines

    S. Jana, A. Ashokan, S. Kumar, A. Verma and S. Kumar, Org. Biomol. Chem., 2015, 13, 8411
    DOI: 10.1039/C5OB01196E

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