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Issue 25, 2015
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An update on new methods to synthesize cyclotetrapeptides

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Abstract

Cyclotetrapeptides are important bioactive lead drug molecules that display a wide spectrum of pharmacological activities. However, the synthesis of cyclotetrapeptides from their linear precursors is challenging due to the highly constrained conformation required for cyclisation, thus hampering their progress to a clinical setting. This review provides an account of the reported methods used for the synthesis of cyclotetrapeptides.

Graphical abstract: An update on new methods to synthesize cyclotetrapeptides

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Article information


Submitted
01 May 2015
Accepted
21 May 2015
First published
21 May 2015

Org. Biomol. Chem., 2015,13, 6906-6921
Article type
Review Article
Author version available

An update on new methods to synthesize cyclotetrapeptides

L. M. De Leon Rodriguez, A. J. Weidkamp and M. A. Brimble, Org. Biomol. Chem., 2015, 13, 6906
DOI: 10.1039/C5OB00880H

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