Min Jiang, Fangxia Zhu, Haoyue Xiang, Xing Xu, Lianfu Deng and Chunhao Yang
Org. Biomol. Chem., 2015,13, 6935-6939
DOI:
10.1039/C5OB00858A,
Communication
An efficient and practical approach to trifluoromethylthiolation of α-haloketones/α-haloarylmethanes was developed. The transformation employs only AgSCF3 and KI in situ generated active nucleophilic trifluoromethylthio species and cleanly occurs in up to quantitative yield at room temperature, thereby providing an unprecedentedly easy entry to various α-SCF3-substituted ketones/arylmethanes.
