Yong Wang, Ya-Nan Xu, Guo-Sheng Fang, Hong-Jian Kang, Yonghong Gu and Shi-Kai Tian
Org. Biomol. Chem., 2015,13, 5367-5371
DOI:
10.1039/C5OB00671F,
Communication
A range of primary allylic amines were resolved with selectivity factors of up to 491 through [Pd(allyl)Cl]2/(S)-BINAP-catalyzed and mesitylsulfonyl hydrazide-accelerated asymmetric allylic alkylation of malononitriles involving enantioselective C–N bond cleavage under aerobic conditions. Moreover, the reaction proved useful for the asymmetric synthesis of α-branched allyl-substituted malononitriles with high enantiopurity.
