Issue 21, 2015

The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA

Abstract

New water-soluble p-tert-butylthiacalix[4]arenes containing peptide and quaternary ammonium fragments in cone and 1,3-alternate conformations were synthesized and characterized. The interaction of the macrocycles with DNA was studied by UV-spectroscopy, DLS and TEM. It was shown that the interaction of the self-associates based on p-tert-butylthiacalix[4]arenes tetrasubstituted at the lower rim with glycine and quaternary ammonium fragments in cone and 1,3-alternate conformations with DNA led to the formation of particles of about 99–192 nm in size.

Graphical abstract: The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA

Supplementary files

Article information

Article type
Paper
Submitted
18 Mar 2015
Accepted
15 Apr 2015
First published
15 Apr 2015

Org. Biomol. Chem., 2015,13, 5894-5904

The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA

P. L. Padnya, E. A. Andreyko, O. A. Mostovaya, I. Kh. Rizvanov and I. I. Stoikov, Org. Biomol. Chem., 2015, 13, 5894 DOI: 10.1039/C5OB00548E

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