Anniefer N. Magpusao, Kelli Rutledge, Brandon Q. Mercado and Mark W. Peczuh
Org. Biomol. Chem., 2015,13, 5086-5089
DOI:
10.1039/C5OB00402K,
Communication
The synthesis and characterization of new [13]-macrodilactones substituted at stereogenic centers α- to the carbonyl are reported. When one center is substituted, it directs the topology of the macrocycle; when two centers are substituted, both the shape and the topology are influenced. The findings indicate that the number and configuration of α-centers fine-tune macrocyclic structure.
![Graphical abstract: Stereogenic α-carbons determine the shape and topology of [13]-macrodilactones](/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=C5OB00402K "Graphical abstract")
