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Issue 15, 2015
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Palladium-catalyzed dicarbonylative synthesis of tetracycle quinazolinones

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Abstract

An interesting procedure for the synthesis of isoindolo[1,2-b]quinazolin-10(12H)-ones has been developed. Starting from commercially available 2-bromoanilines and 2-bromobenzyl amines, with the assistance of a palladium catalyst, the desired products were isolated in good yields. Notably, this procedure proceeded in a highly selective manner; two molecules of CO were incorporated into the substrates selectively.

Graphical abstract: Palladium-catalyzed dicarbonylative synthesis of tetracycle quinazolinones

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Article information


Submitted
24 Feb 2015
Accepted
12 Mar 2015
First published
12 Mar 2015

Org. Biomol. Chem., 2015,13, 4422-4425
Article type
Communication
Author version available

Palladium-catalyzed dicarbonylative synthesis of tetracycle quinazolinones

C. Shen, N. Y. T. Man, S. Stewart and X. Wu, Org. Biomol. Chem., 2015, 13, 4422
DOI: 10.1039/C5OB00368G

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