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Issue 19, 2015
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Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

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Abstract

We describe a ds-oligonucleotide–peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.

Graphical abstract: Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

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Article information


Submitted
14 Feb 2015
Accepted
03 Mar 2015
First published
03 Mar 2015

Org. Biomol. Chem., 2015,13, 5385-5390
Article type
Paper
Author version available

Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

E. Pazos, C. Portela, C. Penas, M. E. Vázquez and J. L. Mascareñas, Org. Biomol. Chem., 2015, 13, 5385
DOI: 10.1039/C5OB00318K

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