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Issue 17, 2015
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Copper-catalysed cross-coupling: an untapped potential

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Copper is emerging as a viable catalytic metal for cross-coupling reactions to construct carbon–carbon (C–C) bonds. Recent revelations that Cu-catalysts can execute with high efficacy the cross-couplings of a variety of organometallic reagents, including organomagnesium, organoboron, organosilicon, organoindium and organomanganese, with alkyl, aryl and heteroaryl halides clearly demonstrate the versatility of Cu-based catalytic systems in conducting these reactions. In addition, Cu-catalysts are exhibiting a unique reactivity pattern that allows ligandless cross-coupling for aryl–heteroaryl and heteroaryl–heteroaryl bond formation, a transformation that generally requires special custom-designed ligands with Pd-catalysts. This review summarises early discoveries and subsequent advancements made in the area of Cu-catalysed cross-couplings of organometallic reagents with organohalides to form C–C bonds.

Graphical abstract: Copper-catalysed cross-coupling: an untapped potential

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Publication details

The article was received on 31 Jan 2015, accepted on 19 Mar 2015 and first published on 19 Mar 2015

Article type: Review Article
DOI: 10.1039/C5OB00200A
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Citation: Org. Biomol. Chem., 2015,13, 4816-4827
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    Copper-catalysed cross-coupling: an untapped potential

    S. Thapa, B. Shrestha, S. K. Gurung and R. Giri, Org. Biomol. Chem., 2015, 13, 4816
    DOI: 10.1039/C5OB00200A

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