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Issue 10, 2015
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A modular synthesis of functionalised phenols enabled by controlled boron speciation

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Abstract

A modular synthesis of functionalised biaryl phenols from two boronic acid derivatives has been developed via one-pot Suzuki–Miyaura cross-coupling, chemoselective control of boron solution speciation to generate a reactive boronic ester in situ, and oxidation. The utility of this method has been further demonstrated by application in the synthesis of drug molecules and components of organic electronics, as well as within iterative cross-coupling.

Graphical abstract: A modular synthesis of functionalised phenols enabled by controlled boron speciation

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Article information


Submitted
14 Jan 2015
Accepted
21 Jan 2015
First published
21 Jan 2015

Org. Biomol. Chem., 2015,13, 3093-3102
Article type
Paper
Author version available

A modular synthesis of functionalised phenols enabled by controlled boron speciation

J. J. Molloy, R. P. Law, J. W. B. Fyfe, C. P. Seath, D. J. Hirst and A. J. B. Watson, Org. Biomol. Chem., 2015, 13, 3093
DOI: 10.1039/C5OB00078E

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