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Issue 7, 2015
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Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

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Abstract

We constructed a regulation system for DNA secondary structure formation of G-rich sequences using a designed PNA peptide exhibiting an on-to-off switching functionality, depending on the protease activity. This study introduces the new concept of a simple and powerful system for regulating quadruplex-related important biological events.

Graphical abstract: Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

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Publication details

The article was received on 03 Dec 2014, accepted on 04 Dec 2014 and first published on 18 Dec 2014


Article type: Paper
DOI: 10.1039/C4OB02535K
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Citation: Org. Biomol. Chem., 2015,13, 2022-2025
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    Control of guanine-rich DNA secondary structures depending on the protease activity using a designed PNA peptide

    K. Usui, A. Okada, K. Kobayashi and N. Sugimoto, Org. Biomol. Chem., 2015, 13, 2022
    DOI: 10.1039/C4OB02535K

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