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Issue 9, 2015
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Silver catalysed decarboxylative alkylation and acylation of pyrimidines in aqueous media

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Abstract

Decarboxylative alkylation or acylation reactions of simple pyrimidines have been developed in aqueous media. Using aliphatic carboxylic acids or 2-oxocarboxylic acids and pyrimidines as substrates and silver as the catalyst, the 4-substituted alkyl or acyl pyrimidines were isolated in moderate to good yields.

Graphical abstract: Silver catalysed decarboxylative alkylation and acylation of pyrimidines in aqueous media

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Publication details

The article was received on 02 Dec 2014, accepted on 06 Jan 2015 and first published on 06 Jan 2015


Article type: Paper
DOI: 10.1039/C4OB02524E
Org. Biomol. Chem., 2015,13, 2750-2755

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    Silver catalysed decarboxylative alkylation and acylation of pyrimidines in aqueous media

    W. Mai, B. Sun, L. You, L. Yang, P. Mao, J. Yuan, Y. Xiao and L. Qu, Org. Biomol. Chem., 2015, 13, 2750
    DOI: 10.1039/C4OB02524E

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