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Issue 5, 2015
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Copper-catalyzed O-arylation of N-protected 1,2-aminoalcohols using functionalized trivalent organobismuth reagents

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Abstract

The O-arylation of 1,2-aminoalcohols using functionalized triarylbismuth reagents is reported. The reaction can be performed using substoichiometric amounts of copper acetate and operates under mild conditions. Good functional group tolerance is observed, giving access to a range of β-aryloxyamines. The effect provided by the amino group in the arylation reaction is investigated.

Graphical abstract: Copper-catalyzed O-arylation of N-protected 1,2-aminoalcohols using functionalized trivalent organobismuth reagents

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Article information


Submitted
29 Sep 2014
Accepted
28 Nov 2014
First published
09 Dec 2014

Org. Biomol. Chem., 2015,13, 1322-1327
Article type
Communication
Author version available

Copper-catalyzed O-arylation of N-protected 1,2-aminoalcohols using functionalized trivalent organobismuth reagents

P. Petiot, J. Dansereau, M. Hébert, I. Khene, T. Ahmad, S. Samaali, M. Leroy, F. Pinsonneault, C. Y. Legault and A. Gagnon, Org. Biomol. Chem., 2015, 13, 1322
DOI: 10.1039/C4OB02497D

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