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Issue 7, 2015
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Halide inhibition of the copper-catalysed azide–alkyne cycloaddition

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Abstract

Chloride, bromide and iodide are inhibitors of the copper-catalysed azide–alkyne cycloaddition, with iodide exhibiting the most detrimental effects on rates and yields. A study of this inhibition is presented, along with experimental protocols to accommodate the presence of halides in this widely used reaction.

Graphical abstract: Halide inhibition of the copper-catalysed azide–alkyne cycloaddition

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Article information


Submitted
25 Nov 2014
Accepted
16 Dec 2014
First published
24 Dec 2014

Org. Biomol. Chem., 2015,13, 1974-1978
Article type
Communication

Halide inhibition of the copper-catalysed azide–alkyne cycloaddition

R. M. Moorman, M. B. Collier, B. H. Frohock, M. D. Womble and J. M. Chalker, Org. Biomol. Chem., 2015, 13, 1974
DOI: 10.1039/C4OB02479F

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