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Issue 7, 2015
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A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones

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Abstract

A microwave-assisted, multicomponent protocol for the synthesis of substituted 3,4-dihydroquinazolinones via a novel cascade imine/cyclization/aza-Henry reaction sequence is reported. Starting from o-formyl carbamates, a series of structurally diverse 3,4-dihydroquinazolinones was synthesized via a cyclic iminium ion intermediate in moderate to excellent yields. Notably, the reaction is fast, flexible, simple to perform and tolerates a variety of functional groups.

Graphical abstract: A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones

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The article was received on 17 Nov 2014, accepted on 05 Dec 2014 and first published on 05 Dec 2014


Article type: Paper
DOI: 10.1039/C4OB02417F
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Org. Biomol. Chem., 2015,13, 2044-2054

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    A microwave-assisted multicomponent synthesis of substituted 3,4-dihydroquinazolinones

    M. Y. Stevens, K. Wieckowski, P. Wu, R. T. Sawant and L. R. Odell, Org. Biomol. Chem., 2015, 13, 2044
    DOI: 10.1039/C4OB02417F

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