The direct electrophilic α-cyanation of β-keto esters and amides has been developed using a hypervalent iodine benziodoxole-derived cyano reagent. The procedure is accomplished within 10 min and without the use of any catalyst in DMF, at room temperature. Thus, the highly functionalized quaternary carbon-centered nitriles were produced in high to excellent yields.
Y. Wang, J. Qiu, D. Kong, Y. Gao, F. Lu, P. G. Karmaker and F. Chen, Org. Biomol. Chem., 2015, 13, 365 DOI: 10.1039/C4OB02032D
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