Jump to main content
Jump to site search

Issue 2, 2015
Previous Article Next Article

Microwave-assisted preparation of 4-amino-3-cyano-5-methoxycarbonyl-N-arylpyrazoles as building blocks for the diversity-oriented synthesis of pyrazole-based polycyclic scaffolds

Author affiliations

Abstract

The synthesis of 4-amino-3-cyano-N-arylpyrazoles A based on a Thorpe–Ziegler cyclization as the key step has been achieved using microwave activation. Via a new diversity-oriented synthetic pathway, these highly functionalized building blocks allowed the access to various heteroaromatic scaffolds such as pyrazolo-pyridines B, pyrazolo-pyrimidines C and pyrazolo-oxadiazoles D. Interestingly, these platforms contain three to four reactive sites that could be used for post-functionalization in order to further increase the molecular diversity.

Graphical abstract: Microwave-assisted preparation of 4-amino-3-cyano-5-methoxycarbonyl-N-arylpyrazoles as building blocks for the diversity-oriented synthesis of pyrazole-based polycyclic scaffolds

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Sep 2014, accepted on 16 Oct 2014 and first published on 04 Nov 2014


Article type: Paper
DOI: 10.1039/C4OB01951B
Author version
available:
Download author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 409-423

  •   Request permissions

    Microwave-assisted preparation of 4-amino-3-cyano-5-methoxycarbonyl-N-arylpyrazoles as building blocks for the diversity-oriented synthesis of pyrazole-based polycyclic scaffolds

    L. L. Corre, L. Tak-Tak, A. Guillard, G. Prestat, C. Gravier-Pelletier and P. Busca, Org. Biomol. Chem., 2015, 13, 409
    DOI: 10.1039/C4OB01951B

Search articles by author

Spotlight

Advertisements