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Issue 45, 2015
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Shape-controlled gold nanoparticles supported on MoS2 nanosheets: synergistic effect of thionine and MoS2 and their application for electrochemical label-free immunosensing

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Abstract

Herein, a facile approach for shape-controlled gold nanoparticle (AuNP) decorated thionine–MoS2 nanocomposites (AuNP–Thi–MoS2) had been reported by using the synergistic effect of MoS2 and Thi. Thi was not only used as an electrochemical indicator, but also as a reducing agent to tune the resulting morphologies of AuNPs. With the ratio of MoS2/Thi decreasing, the shapes of AuNPs changed from spherical, triangle, clover-like to flower-like nanostructures. TEM, XRD and XPS were employed to characterize the formation and chemical composition of AuNP–Thi–MoS2 nanocomposites. On the basis of synthesis, a MoS2-based label-free electrochemical immunosensor had been designed to detect carcino-embryonic antigen (CEA). The proposed immunosensor could detect as low as 0.52 pg mL−1 CEA with excellent selectivity. Moreover, the expected immunosensor showed high stability and excellent reproducibility, which could detect CEA in human serum with satisfactory results. Therefore, the AuNP–Thi–MoS2 nanocomposites may be considered as a candidate sensing platform for fabrication of simple, label-free and ultrasensitive electrochemical sensors.

Graphical abstract: Shape-controlled gold nanoparticles supported on MoS2 nanosheets: synergistic effect of thionine and MoS2 and their application for electrochemical label-free immunosensing

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Publication details

The article was received on 19 Aug 2015, accepted on 15 Oct 2015 and first published on 20 Oct 2015


Article type: Paper
DOI: 10.1039/C5NR05614D
Citation: Nanoscale, 2015,7, 19129-19135

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    Shape-controlled gold nanoparticles supported on MoS2 nanosheets: synergistic effect of thionine and MoS2 and their application for electrochemical label-free immunosensing

    S. Su, M. Zou, H. Zhao, C. Yuan, Y. Xu, C. Zhang, L. Wang, C. Fan and L. Wang, Nanoscale, 2015, 7, 19129
    DOI: 10.1039/C5NR05614D

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