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Issue 40, 2015
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Rational design of a photo-responsive UVR8-derived protein and a self-assembling peptide–protein conjugate for responsive hydrogel formation

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Abstract

Responsive hydrogels hold great potential in controllable drug delivery, regenerative medicine, sensing, etc. We introduced in this study the first example of a photo-responsive protein for hydrogel formation. Based on the first example of the crystal structure of a photo-responsive protein, Arabidopsis thaliana protein UVR8, we designed and expressed its derived protein UVR8-1 with a hexa-peptide WRESAI. We also prepared supramolecular nanofibers with a TIP-1 protein at their surface. The simple mixing of these two components resulted in rapid hydrogel formation through the specific interactions between the protein TIP-1 and the peptide WRESAI. Since the protein could show a reversible dimer–monomer transformation, the resulting gels also showed a reversible gel–sol phase transition which was controlled by photo-irradiation. The photo-controllable gel–sol phase transition could be applied for protein delivery and cell separation.

Graphical abstract: Rational design of a photo-responsive UVR8-derived protein and a self-assembling peptide–protein conjugate for responsive hydrogel formation

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Supplementary files

Article information


Submitted
03 Aug 2015
Accepted
29 Aug 2015
First published
08 Sep 2015

Nanoscale, 2015,7, 16666-16670
Article type
Paper

Rational design of a photo-responsive UVR8-derived protein and a self-assembling peptide–protein conjugate for responsive hydrogel formation

X. Zhang, C. Dong, W. Huang, H. Wang, L. Wang, D. Ding, H. Zhou, J. Long, T. Wang and Z. Yang, Nanoscale, 2015, 7, 16666
DOI: 10.1039/C5NR05213K

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