Issue 43, 2015
From the journal:

Nanoscale

A reversible metal ion fueled DNA three-way junction molecular device for “turn-on and -off” fluorescence detection of mercury ions (II) and biothiols respectively with high selectivity and sensitivity†

Long Ma,*abc   Guanrong Wu,bc   Yufeng Li,bc   Ping Qin,bc   Lingpei Meng,bc   Haiyan Liu,bc   Yuyin Libc  and  Aipo Diaobc  

* Corresponding authors

a Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, School of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China
E-mail: malong@tust.edu.cn
Fax: +86 22 60602298
Tel: +86 22 60602948

b Tianjin Key Laboratory of Industry Microbiology, School of Biotechnology, Tianjin University of Science & Technology, Tianjin 300457, China
Tel: +0133 446 7254

c Biomolecular Sciences Research Complex, EaStCHEM School of Chemistry, University of St Andrews, Fife KY16 9ST, UK
E-mail: lm228@st.andrews.ac.uk

Abstract

We constructed a reversible molecular device in the nanoscale based on a DNA three-way junction (3WJ) fueled by Hg2+ binding and sequestration. It is highly responsive to external stimuli, which brings about optically detectable global structural changes. Such a DNA device can serve as a novel “turn-on and -off” fluorescent sensor for Hg2+ and biothiol detection with high selectivity and sensitivity.

Graphical abstract: A reversible metal ion fueled DNA three-way junction molecular device for “turn-on and -off” fluorescence detection of mercury ions (II) and biothiols respectively with high selectivity and sensitivity

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Article information

DOI
https://doi.org/10.1039/C5NR04688B
Article type
Communication
Submitted
13 Jul 2015
Accepted
24 Sep 2015
First published
21 Oct 2015

Nanoscale, 2015,7, 18044-18048

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A reversible metal ion fueled DNA three-way junction molecular device for “turn-on and -off” fluorescence detection of mercury ions (II) and biothiols respectively with high selectivity and sensitivity

L. Ma, G. Wu, Y. Li, P. Qin, L. Meng, H. Liu, Y. Li and A. Diao, Nanoscale, 2015, 7, 18044 DOI: 10.1039/C5NR04688B

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