Issue 31, 2015
From the journal:

Nanoscale

Magnetic field activated drug delivery using thermodegradable azo-functionalised PEG-coated core–shell mesoporous silica nanoparticles†

P. Saint-Cricq, ORCID logo ‡a   S. Deshayes,‡b   J. I. Zink*a  and  A. M. Kasko*b  

* Corresponding authors

a Department of Chemistry and Biochemistry, and California NanoSystems Institute, University of California Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095, USA
E-mail: zink@chem.ucla.edu

b Bioengineering Department, and California NanoSystems Institute University of California Los Angeles, 410 Westwood Plaza, Los Angeles, California 90095-1600, USA
E-mail: akasko@ucla.edu

Abstract

Core–shell Fe3O4@SiO2 mesoporous silica nanoparticles coated with a new thermodegradable polymer allowed the release of a model drug through heating caused by a high frequency oscillating magnetic field. The thermodegradable polymer was made of poly(ethylene glycol) (PEG) functionalised with azo bonds that break with an elevation of temperature.

Graphical abstract: Magnetic field activated drug delivery using thermodegradable azo-functionalised PEG-coated core–shell mesoporous silica nanoparticles

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Article information

DOI
https://doi.org/10.1039/C5NR03777H
Article type
Communication
Submitted
08 Jun 2015
Accepted
02 Jul 2015
First published
06 Jul 2015

Nanoscale, 2015,7, 13168-13172

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Magnetic field activated drug delivery using thermodegradable azo-functionalised PEG-coated core–shell mesoporous silica nanoparticles

P. Saint-Cricq, S. Deshayes, J. I. Zink and A. M. Kasko, Nanoscale, 2015, 7, 13168 DOI: 10.1039/C5NR03777H

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