Issue 37, 2015

Nanoscale-alumina induces oxidative stress and accelerates amyloid beta (Aβ) production in ICR female mice

Abstract

The adverse effects of nanoscale-alumina (Al2O3-NPs) have been previously demonstrated in both in vitro and in vivo studies, whereas little is known about their mechanism of neurotoxicity. It is the goal of this research to determine the toxic effects of nano-alumina on human neuroblastoma SH-SY5Y and mouse hippocampal HT22 cells in vitro and on ICR female mice in vivo. Nano-alumina displayed toxic effects on SH-SY5Y cell lines in three different concentrations also increased aluminium abundance and induced oxidative stress in HT22 cells. Nano-alumina peripherally administered to ICR female mice for three weeks increased brain aluminium and ROS production, disturbing brain energy homeostasis, and led to the impairment of hippocampus-dependent memory. Most importantly, these nano-particles induced Alzheimer disease (AD) neuropathology by enhancing the amyloidogenic pathway of Amyloid Beta (Aβ) production, aggregation and implied the progression of neurodegeneration in the cortex and hippocampus of these mice. In conclusion, these data demonstrate that nano-alumina is toxic to both cells and female mice and that prolonged exposure may heighten the chances of developing a neurodegenerative disease, such as AD.

Graphical abstract: Nanoscale-alumina induces oxidative stress and accelerates amyloid beta (Aβ) production in ICR female mice

Article information

Article type
Paper
Submitted
01 Jun 2015
Accepted
07 Aug 2015
First published
11 Aug 2015

Nanoscale, 2015,7, 15225-15237

Author version available

Nanoscale-alumina induces oxidative stress and accelerates amyloid beta (Aβ) production in ICR female mice

S. A. Shah, G. H. Yoon, A. Ahmad, F. Ullah, F. U. Amin and M. O. Kim, Nanoscale, 2015, 7, 15225 DOI: 10.1039/C5NR03598H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements