Cytotoxicity, tumor targeting and PET imaging of sub-5 nm KGdF4 multifunctional rare earth nanoparticles

Xinmin Cao; Fengwen Cao; Liqin Xiong; Yang Yang; Tianye Cao; Xi Cai; Wangxi Hai; Biao Li; Yixiao Guo; Yimin Zhang; Fuyou Li

doi:10.1039/C5NR03374H

Cytotoxicity, tumor targeting and PET imaging of sub-5 nm KGdF₄ multifunctional rare earth nanoparticles†

Xinmin Cao,^a Fengwen Cao,^a Liqin Xiong,*^ab Yang Yang,^c Tianye Cao,^d Xi Cai,^a Wangxi Hai,^b Biao Li,^b Yixiao Guo,^a Yimin Zhang^a and Fuyou Li^c

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* Corresponding authors

^a School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. China
E-mail: xiongliqin@sjtu.edu.cn

^b Department of Nuclear Medicine, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China

^c Department of Chemistry & The State Key Laboratory of Molecular Engineering of Polymers & Institute of Biomedicine Science, Fudan University, Shanghai, P. R. China
E-mail: fyli@fudan.edu.cn

^d Department of Nuclear Medicine, Fudan University Shanghai Cancer Center & Department of Oncology, Shanghai Medical College & Center for Biomedical Imaging, Fudan University, Shanghai, P. R. China

Abstract

Ultrasmall sub-5 nm KGdF₄ rare earth nanoparticles were synthesized as multifunctional probes for fluorescent, magnetic, and radionuclide imaging. The cytotoxicity of these nanoparticles in human glioblastoma U87MG and human non-small cell lung carcinoma H1299 cells was evaluated, and their application for in vitro and in vivo tumor targeted imaging has also been demonstrated.

Nanoscale

Cytotoxicity, tumor targeting and PET imaging of sub-5 nm KGdF₄ multifunctional rare earth nanoparticles†

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Cytotoxicity, tumor targeting and PET imaging of sub-5 nm KGdF₄ multifunctional rare earth nanoparticles

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