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Issue 25, 2015
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Highly sensitive detection for proteins using graphene oxide-aptamer based sensors

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Abstract

In recent years, the detection of proteins by using bare graphene oxide (GO) to quench the fluorescence of fluorescein-labeled aptamers has been reported. However, the proteins can be adsorbed on the surface of bare GO to prevent the sensitivity from further being improved. In order to solve this problem, polyethylene glycol (PEG)-protected GO was used to prevent the proteins using thrombin as an example from nonspecific binding. The detection limit was improved compared to bare GO under the optimized ratio of GO to PEG concentration. The results show that our method is a promising technique for the detection of proteins.

Graphical abstract: Highly sensitive detection for proteins using graphene oxide-aptamer based sensors

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Publication details

The article was received on 21 Feb 2015, accepted on 16 Apr 2015 and first published on 22 Apr 2015


Article type: Communication
DOI: 10.1039/C5NR01187F
Citation: Nanoscale, 2015,7, 10903-10907

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    Highly sensitive detection for proteins using graphene oxide-aptamer based sensors

    L. Gao, Q. Li, R. Li, L. Yan, Y. Zhou, K. Chen and H. Shi, Nanoscale, 2015, 7, 10903
    DOI: 10.1039/C5NR01187F

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