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Issue 21, 2015
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Ordering in bio-inorganic hybrid nanomaterials probed by in situ scanning transmission X-ray microscopy

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Abstract

Phospholipid bilayer coated Si nanowires are one-dimensional (1D) composites that provide versatile bio-nanoelectronic functionality via incorporation of a wide variety of biomolecules into the phospholipid matrix. The physiochemical behaviour of the phospholipid bilayer is strongly dependent on its structure and, as a consequence, substantial modelling and experimental efforts have been directed at the structural characterization of supported bilayers and unsupported phospholipid vesicles; nonetheless, the experimental studies conducted to date have exclusively involved volume-averaged techniques, which do not allow for the assignment of spatially resolved structural variations that could critically impact the performance of the 1D phospholipid-Si NW composites. In this manuscript, we use scanning transmission X-ray microscopy (STXM) to probe bond orientation and bilayer thickness as a function of position with a spatial resolution of ∼30 nm for Δ9-cis 1,2-dioleoyl-sn-glycero-3-phosphocholine layers prepared Si NWs. When coupled with small angle X-ray scattering measurements, the STXM data reveal structural motifs of the Si NWs that give rise to multi-bilayer formation and enable assignment of the orientation of specific bonds known to affect the order and rigidity of phospholipid bilayers.

Graphical abstract: Ordering in bio-inorganic hybrid nanomaterials probed by in situ scanning transmission X-ray microscopy

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Supplementary files

Article information


Submitted
27 Jan 2015
Accepted
01 Apr 2015
First published
15 Apr 2015

Nanoscale, 2015,7, 9477-9486
Article type
Paper

Ordering in bio-inorganic hybrid nanomaterials probed by in situ scanning transmission X-ray microscopy

J. R. I. Lee, M. Bagge-Hansen, R. Tunuguntla, K. Kim, M. Bangar, T. M. Willey, I. C. Tran, D. A. Kilcoyne, A. Noy and T. van Buuren, Nanoscale, 2015, 7, 9477
DOI: 10.1039/C5NR00622H

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