Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 12, 2015
Previous Article Next Article

In situ synthesis of luminescent carbon nanoparticles toward target bioimaging

Author affiliations

Abstract

This paper describes the in situ synthesis of single fluorescence carbon nanoparticles (FCNs) for target bioimaging applications derived from biocompatible hyaluronic acid (HA) without using common conjugation processes. FCNs formed via the dehydration of hyaluronic acid, which were obtained by carbonizing HA, and partially carbonized HA fluorescence carbon nanoparticles (HA-FCNs), formed by a lower degree of carbonization, show good aqueous solubility, small particle size (<20 nm) and different fluorescence intensities with a red shift. After confirming the cytotoxicity of HA-FCNs and FCNs, we carried out in vitro and in vivo bioimaging studies where HA-FCNs themselves functioned as single particle triggers in target imaging. The converted nanocrystal carbon particles from HA provide outstanding features for in vitro and in vivo new targeted delivery and diagnostic tools.

Graphical abstract: In situ synthesis of luminescent carbon nanoparticles toward target bioimaging

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Dec 2014, accepted on 17 Feb 2015 and first published on 23 Feb 2015


Article type: Paper
DOI: 10.1039/C4NR07422J
Author version
available:
Download author version (PDF)
Citation: Nanoscale, 2015,7, 5468-5475

  •   Request permissions

    In situ synthesis of luminescent carbon nanoparticles toward target bioimaging

    S. Md. Sharker, S. M. Kim, J. E. Lee, J. H. Jeong, I. In, K. D. Lee, H. Lee and S. Y. Park, Nanoscale, 2015, 7, 5468
    DOI: 10.1039/C4NR07422J

Search articles by author

Spotlight

Advertisements